| Indications: |
| Antihypertensive ( Angiotensin II Antagonist) |
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| Description |
LOSARTAN is an angiotension II receptor antagonist with antihypertensive activity due mainly to selective blocked of AT1 receptors and the consequent reduced pressor effect of angiotension II.
Neither LOSARTAN nor its potent active metabolite inhibits ACE (Kininase II, the enzyme that converts angiotensin I to angiotensin II and degrades bradykinin ) nor do they bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.
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| Composition |
Each film coated tablet contains: LOSARTAN Potassium 50 mg
Each film coated tablet contains: LOSARTAN Potassium 25 mg
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| Detailed Indications: |
- LOSARTAN is indicated for the treatment of hypertension.
It may be used alone or in combination with other antihypertensive agents.
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| Contraindications: |
Hypersensitivity to any component of this product. |
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| Packing: |
In general, treatment with LOSARTAN is well - tolerated.
It may rarely cause dizziness, increase in serum potassium, symptomatic Hypotension especially in patients treated with diuretics or having a poor sodium intake, or suffering of vomiting and diarrhoea.
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| Drug Interaction: |
There is no significant drug-drug pharmacokinetic interactions with hydrochlorothiazide, digoxine, Warferine, Cimetidine and phenobarbital. As with other drugs that block Angiotensin II or its effects, concomitant use of potassium, sparing diuretics (e.g. spironolactone, triamterene, amiloride ) potassium supplements, or oral substitutes containing potassium may lead to increase in serum potassium. |
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| Dosage & Administration: |
Usual starting dose: 50 mg once daily.
- LOSARTAN can be administered once or twice daily with total daily doses ranging from 25 mg to 100 mg .
- In patients with possible depletion of intravascular volume (e.g. patients treated with diuretics) : 25 mg .
- LOSARTAN may be administered with other antihypertensive agents.
- LOSARTAN may be administered with or without food. |
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| Precautions: |
- Pregnancy :
When patients become pregnant, physicians should have the patient discontinue the use of LOSARTAN.
- Impaired Hepatic Function :
A lower dose should be considered.
- Impaired Renal Function :
Care should be taken in patients whose renal function may depend on the activity
of the renin - angiotension aldosterone systems (e.g. patients with severe congestive
heart failure). |
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| Packing: |
- 10 tablet in blister.
- 2 blister in a pack.
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