Dosing: Adult Bronchitis, acute (and exacerbations of chronic bronchitis): Oral: 250-500 mg every 12 hours for 10 days
I.V.: 500-750 mg every 8 hours (complete therapy with oral dosing)
Gonorrhea:Disseminated: I.M., I.V.: 750 mg every 8 hours
Uncomplicated:
Oral: 1 g as a single dose
I.M.: 1.5 g as single dose (administer in two different sites with probenecid)
Intra-abdominal infection, complicated, community-acquired, mild-to-moderate (in combination with metronidazole): 1.5 g every 8 hours for 4-7 days (provided source controlled)
Pharyngitis/tonsillitis and sinusitis: Oral: 250 mg twice daily for 10 days
Skin/skin structure infection, uncomplicated: Oral: 250-500 mg every 12 hours for 10 days
I.M., I.V.: 750 mg every 8 hours
Pneumonia, uncomplicated: I.M., I.V.: 750 mg every 8 hours
Severe or complicated infections: I.M., I.V.: 1.5 g every 8 hours (up to 1.5 g every 6 hours in life-threatening infections)
Surgical prophylaxis: I.V.: 1.5 g 30 minutes to 1 hour prior to procedure (if procedure is prolonged can give 750 mg every 8 hours I.M.)
Cholecystectomy: I.V.: 1.5 g every 8 hours, discontinue within 24 hours unless infection outside gallbladder suspected
Open heart: I.V.: 1.5 g every 12 hours to a total of 6 g
Urinary tract infection, uncomplicated: Oral: 125-250 mg twice daily for 7-10 days
I.V., I.M.: 750 mg every 8 hours
Dosing: Pediatric Children 3 months to 12 years:
Acute otitis media, impetigo: Oral: Suspension: 30 mg/kg/day (maximum: 1 g/day) in 2 divided doses for 10 days
Tablet: 250 mg every 12 hours for 10 days
I.M., I.V.: 75-150 mg/kg/day divided every 8 hours (maximum dose: 6 g/day)
Acute bacterial maxillary sinusitis: Oral:
Suspension: 30 mg/kg/day in 2 divided doses for 10 days (maximum dose: 1 g/day)
Tablet: 250 mg twice daily for 10 days
Meningitis: NOT recommended (doses of 200-240 mg/kg/day divided every 6-8 hours have been used) (maximum dose: 9 g/day)
Pharyngitis, tonsillitis: Oral: Suspension: 20 mg/kg/day (maximum: 500 mg/day) in 2 divided doses for 10 days
Tablet: 125 mg every 12 hours for 10 days
I.M., I.V.: 75-150 mg/kg/day divided every 8 hours; maximum dose: 6 g/day
Children ≥13 years: Refer to adult dosing.
Dosing: Renal Impairment Clcr 10-20 mL/minute: Administer every 12 hours.
Clcr <10 mL/minute: Administer every 24 hours.