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Product Name
Chemical Name
Pefloxacin (Mesilate Dihydrate)
Therapeutic Category
Pharmacologic Category
Antibiotic, Quinolone
Pharmaceutical Form
Pefloxacin (Mesilate Dihydrate) 400mg/5ml
Monitoring Parameters
Mechanism of Action
Pharmacodynamics / Kinetics
Dosing: Adult
Intravenously: Injections of PEFLOZ must be prescribed in slow intravenous infusion (1 hour) after dilution of the 400 mg ampoule into 250 ml of 5% glucose solution (2 injections per day in the morning and evening). Saline solution (NaCl) or any other solution containing chlorine ions must not be added because of the risk of precipitation.

Dosage: - In adults with normal hepatic function: average of 800 mg/day. - A first dose of 800 mg may be indicated to reach efficacious blood levels more rapidly.

In adults with hepatic insufficiency: The daily dose must be adapted in patients suffering from severe hepatic insufficiency or reduced hepatic blood flow by increasing the interval in between two administration. A more specific method may be recommended for intravenous injections: 8 mg/kg body weight in 1 hour infusion: - Twice a day in the absence of absence of icterus or ascites. - Once a day in the presence of icterus. - Every 36 hours in the presence of ascites. - Every other day in the presence of both icterus and ascites.
In adults, they are restricted to severe infections with gram-negative bacilli and staphylococci that are susceptible; namely in their following manifestations: - Septicemic, endocarditic, Meningeal, Respiratory, Otorhinolaryngologic,
Adverse Reactions
It may rarely cause: Photosensitization and cutaneous eruptions, muscular and/or joint pain, headaches, insomnia,gastric pain, nausea and vomiting. All these disorders are reversible upon discontinuation of treatment.
- Allergy to quinolone. - Children under 15 years of age. - Deficiency in glucose-6-phosphate dehydrogenase. - Pregnancy and Lactation.
Warnings / Precautions Drug
1- Severe hepatic insufficiency: Dosage should be adjusted accordingly.
2- The patient must not be exposed to sunlight nor UV light during treatment because of the risk of photosensitization.
3- Streptococci and pneumococci are not always susceptible to Pefloxacin. The antibiotic must therefore not be used as the primary treatment of non-nosocomial respiratory infections, in the absence of any specific bacteriologic study
 It is advised not to use the drug with anti-acids.
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