Product Name
:
MAXIM
Chemical Name
:
Ampicillin (Sodium)+Cloxacillin (Sodium)
Therapeutic Category
:
Antimicrobial
Pharmacologic Category
:
Antibiotic, Penicillin
Pharmaceutical Form
:
Vial
Composition
:
Ampicillin 250mg+Cloxacillin 250mg / Ampicillin 500mg+Cloxacillin 500mg
Dosing
 
Oral
Susceptible infections
Adult: Per capsule contains ampicillin 250 mg and cloxacillin 250 mg: 1 capsule 4 times daily. In severe infections, the dose can be increased up to 12 capsules daily.
Child: Per dose contains ampicillin 125 mg and cloxacillin 125 mg: 1 dose 4 times daily.
Intramuscular
Moderate to severe infections
Adult: 250 mg (ampicillin 125 mg + cloxacillin 125 mg) every 6 hr.
Intramuscular
Moderate to severe infections
Adult: 500 mg (ampicillin 250 mg and cloxacillin 250 mg) or 1 g (ampicillin 500 mg and cloxacillin 500 mg) every 6 hr. Doses higher than 500 mg should be given in two different sites of not more than 500 mg in 3ml.
Intramuscular
Severe infections
Adult: 500 mg (ampicillin 250 mg and cloxacillin 250 mg) or 1 g (ampicillin 500 mg and cloxacillin 500 mg) every 6 hr. Doses higher than 500 mg should be given in two different sites of not more than 500 mg in 3ml.
Intravenous
Severe infections
Adult: 500 mg (ampicillin 250 mg and cloxacillin 250 mg) in 10 ml or 1 g (ampicillin 500 mg and cloxacillin 500 mg) in 20 ml of water for inj. Given slowly over 3-4 minutes, repeated every 6 hr.
Child: 2-10 yr: Half the adult dose. < 2 yr: Quarter of adult dose.
Use
 
Treatment of susceptible bacterial infections (nonbeta-lactamase-producing organisms); treatment or prophylaxis of infective endocarditis; susceptible bacterial infections caused by streptococci, pneumococci, nonpenicillinase-producing staphylococci, Listeria, meningococci; some strains of H. influenzae, Salmonella, Shigella, E. coli, Enterobacter, and Klebsiella
Adverse Reactions
 
G.I.disturbances, pruritus, urticaria, erythema, exfoliative dermatitis, rashes, fever, joint pain, eosinophilia, bronchial asthma, angioneuratic oedema, hemolytic anaemia, serum sickness, CNS effects like hyperactivity, agitation, insomnia, anxiety, behavioural changes, confusion, dizziness and convulsions.
Potentially Fatal: Anaphylactic reaction.
Contraindications
 

Penicillin allergy.

Warnings / Precautions Drug
 
Allergy to cephalosporins, infectious mononucleosis, neonates with jaundice, history of convulsions, lactation
Interactions
 
Failure of oral contraceptives, increased rash with allopurinol, reduced bactericidal activity with chloramphenicol, erythromycin and tetracyclines.
Pregnancy
 
Pregnancy Implications
this medication is considered safe. You should however still consult your doctor before use.
Lactation
 
This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Mechanism of Action
 
Ampicillin exerts bactericidal action on both gm+ve and gm-ve organisms. Its spectrum includes gm+ve organisms eg, S pneumoniae and other Streptococci, L monocytogenes and gm-ve bacteria eg, M catarrhalis, N gonorrhoea, N meningitidis, E coli, P mirabilis, Salmonella, Shigella, and H influenzae. Ampicillin exerts its action by inhibiting the synthesis of bacterial cell wall. Cloxacillin is a penicillinase-resistant penicillin. It is active against gm+ve organisms including penicillinase-producing strains of Staphylococci. Cloxacillin is highly active against Staph aureus, Strep pyogenes, Strep viridans and Strep pneumoniae. It is also active against penicillinase-producing gonococci and against N meningitidis and H influenzae. Other gm-ve organisms are resistant to cloxacillin as are also methicillin-resistant strains of Staphylococci.